Well there’s a new development around the health effects of styrene, that’s been hotly contested for … Styrene is a colorless to yellow liquid that is highly flammable and evaporates easily. Styrene Modeling includes detailed, how-to modeling advice from more than a dozen accomplished craftsmen who have built every conceivable type of styrene model. Hearing … ScienceDaily. Aarhus University. 12th Report on Carcinogens, National Toxicology Program, Cytogenetic and DNA damage on workers exposed to styrene, Styrene metabolism, genotoxicity, and potential carcinogenicity, Styrene Oxide CAS No. (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). Reasonably Anticipated to Be a Human Carcinogen. Styrene has been classified by the International Agency for Research on Cancer (IARC) as Group 2A, probably carcinogenic to humans, based on limited human and sufficient animal evidence. James Huff, Peter F. Infante, Styrene exposure and risk of cancer, Mutagenesis, Volume 26, Issue 5, September 2011, Pages 583–584, https://doi.org/10.1093/mutage/ger033. Styrene is the precursor … National Institute of Environmental Health Sciences, National Institutes of Health. Styrene is an industrial chemical used to produce a number of different … For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Butadiene or styrene or butadiene and styrene or else? Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. 96-09-3. Additional evidence for styrene and human cancers is supported by carcinogenesis bioassays as sufficient evidence for the carcinogenicity of styrene in experimental animals based on the induction of tumours in multiple studies in mice exposed to styrene by two routes of exposure. Although some studies suggest that styrene-exposed workers may be at increased cancer risk, the human evidence for styrene carcinogenicity is inconclusive. save. There are no strong or consistent indications that styrene causes any form of cancer in humans. 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Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. ScienceDaily shares links with sites in the. Title: Formaldehyde, Styrene Cancer Warning. He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Philadelphia-negative myeloproliferative neoplasms among Kuwaiti Nationals. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. After this stage, the information was linked with the Danish Cancer Register to assess the incidence of different types of cancer among the employees compared to the general population's risk of developing the same diseases. For permissions, please e-mail: journals.permissions@oup.com. "Possibly carcinogenic and should be investigated more closely." Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. Styrene news and market information products from ICIS. The latter cover cause-effect studies based on biological material. We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene Questions? Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Aarhus University. Mette Skovgaard Christensen, Jesper Medom Vestergaard, Francesco d’Amore, Jette Sønderskov Gørløv, Gunnar Toft, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Inge Brosbøl Iversen, Mette Schou Nissen, Henrik Albert Kolstad. The conclusion that diets can play a role in lowering or increasing cancer … Styrene - ToxFAQs™ CAS # 100-42-5. Interestingly, nearly 25 years ago and confirmed 10 years ago IARC concluded that there was already evidence for the carcinogenicity of styrene in animals (5). Oxford University Press is a department of the University of Oxford. report. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … Other countries have done nothing. Government scientists effectively have seen just enough evidence to posit a link between styrene and cancer, but not enough for ironclad proof. "That part of the study is primarily based on measurements that the Danish Working Environment Authority carried out a number of years ago, since the Danish Working Environment Authority has not carried out measurements of styrene over the past several years. Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. He is pleased with the fact that we in Denmark are able to do something that no other country can: "The reason for my presence in the working group is our register-based research, which is unique throughout the world, and where the most recent styrene study shows the risk of acute myeloid leukaemia, a rare form of leukemia, is doubled. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … Styrene news and market information products from ICIS. Chapter 1, The Case for Styrene… Cancer Studies in Humans The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) in-creased mortality from or incidence of cancer of the lymphohemato- poietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. Aarhus University. Four styrene-laden products to ditch. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. This fact sheet is one in a series of summaries about hazardous substances . Additionally, increases in cancer ‘at these sites were also observed in some of the individual cohort studies, and there was some evidence of an exposure–response relationship with pancreatic cancer’ (1). Standardized … Human Studies: The limited evidence for cancer from styrene in humans is from occupational studies showing increased risks for lymphohematopoietic cancers, such as leukemia and lymphoma, and genetic damage in the white blood cells, or lymphocytes, of workers exposed to styrene. About the United Kingdom Environmental Mutagen Society, http://ntp.niehs.nih.gov/?objectid=BD1A20B5-F1F6-975E-7CF8CBFACF0FC7EF, http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/StyreneOxide.pdf, http://www.ehjournal.net/content/10/S1/S14, Receive exclusive offers and updates from Oxford Academic, Comparison of genotoxic potency of styrene 7,8-oxide with γ radiation and human cancer risk estimation of styrene using the rad-equivalence approach, Styrene monomer does not induce unscheduled DNA synthesis in the mouse liver following inhalation exposure. Reddit; Wechat; Abstract. Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). The predictive value of rodent carcinogenicity tests in the evaluation of human risks, Chemicals and cancer in humans: first evidence in experimental animals, Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance, Lorenzo Tomatis and primary prevention of environmental cancer. Causality is not established, as the possibility that the results were due to chance or to confounding by exposure to other carcinogenic chemicals cannot be completely ruled out. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. These collective carcinogenicity findings clearly support, predated and predicted styrene carcinogenicity in humans (14–21), as nearly one-third of known human carcinogens were first identified in long-term bioassays (22–25). Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. Back-up Slides Styrene Exposure Scenarios . For more information, call the ATSDR Information Center at 1-800-232-4636. The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. Methods. Many companies take measurements, but they are not publicly available. In the research project, PhD student Mette Skovgaard Christensen, Henrik Kolstad and their research colleagues followed 73,036 employees who during the period 1968-2011 worked in one of the 456 small and medium-sized companies in Denmark that have used styrene in the production of e.g. Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies from Aarhus together with new animal evidence. Materials provided by Aarhus University. The Factors That Do Increase Cancer Risk. IARC’s (5) evaluation of the available human studies nearly 10 years ago stated ‘There is limited evidence in humans for the carcinogenicity of styrene’, which indicates evidence of a credible but not a clear demonstration of a causal association with lymphatic/hematopoietic neoplasms in humans. WARNING: This product contains a chemical known to the State of California to cause cancer, birth defects or other reproductive harm. The Boffetta et al. Some scientists think it’s already over. Four styrene laden products to ditch Planning a summer barbecue this weekend or stocking up for Labor Day? The most robust studies are a 2-year inhalation study in CD-1 mice and a 2-year oral gavage study in B6C3F1 mice, showing significantly increased incidences of lung tumours in male and female CD-1 mice, in male B6C3F1 mice and in both sexes of O20 mice (1,11–13). Issues, controversies, and uncertainties. In California this led to requirements for special product labelling, while EU countries do not have to label Roundup as a carcinogen. What is styrene? Styrene is on the Proposition 65 list because it can cause cancer. This part of the study is published in Occupational and Environmental Medicine in the article 'Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry'. Content on this website is for information only. "Clearly, the best place to study the possible health effects of styrene exposure is in the reinforced plasticsindustry, where no butadiene is involved. The NTP independent Board was not swayed or particularly impressed with the analysis and conclusions of the Boffetta et al. The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … Search for other works by this author on: Styrene. Styrene is included in synthetic rubber, some insulation materials, disposable tableware, packaging and fiberglass plastic. Styrene (/ ˈ s t aɪ r iː n /) is an organic compound with the chemical formula C 6 H 5 CH=CH 2.This derivative of benzene is a colorless oily liquid, although aged samples can appear yellowish.The compound evaporates easily and has a sweet smell, although high concentrations have a less pleasant odor. This thread is … Exposure to styrene may increase the risk of cancer. Another example is the monograph that last year found that the herbicide glyphosate, better known as Roundup, can be carcinogenic. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… "We've tried to make it clear that a listing in the report doesn't necessarily mean that encountering that substance in any minute quantity means you'll get cancer," said NTP Associate Director John Bucher. But now an impartial working group under the auspices of WHO and appointed by the International Agency for Research on Cancer (IARC), has upgraded the warning. 100% Upvoted. Such frustration is understandable. It's a handbook no modeler should be without. Planning a summer barbecue this weekend or stocking up for Labor Day? Reddit; Founded in 1976 ... the singer has revealed she’s battling breast cancer. (9) in 2010 likewise demonstrated significantly elevated risks in petrochemical workers exposed to styrene when data for all categories of non-Hodgkin’s lymphoma are combined (Standardized Incidence Ratio = 1.87, 95% CI = 1.01–2.99, based on 15 cases) (10). The European Union undertook a risk assessment of styrene and concluded that, “based on human studies, there is no clear and consistent evidence for a causal link between specific cancer mortality and exposure to styrene” (EU 2008, p. 271). Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. (2018, May 30). Indeed, Boffetta et al. The facilities have since closed but, when operational, manufactured boats using styrene … Styrene (vinyl benzene) is an economically important industrial chemical used in the synthesis and manufacture of polystyrene and hundreds of different copolymers, as well as numerous other industrial resins. What about other health effects? In March, the 23 researchers in the WHO working group spent ten intensive working days in Lyon, where they had the task of reviewing and re-evaluating the carcinogenic risk based on the latest research on styrene exposure which includes epidemiological studies of humans together with animal experiments and what are known as mechanism studies. (8) who reported significantly elevated risks for B-cell non-Hodgkin’s lymphoma [odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.1–2.3] and for follicular lymphoma (OR = 2.6; 95% CI = 1.3–5.2) in relation to styrene exposure. Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. He is professor in occupational medicine, at the Department of Clinical Medicine at Aarhus University as well as Aarhus University Hospital. Budroni et al. The 2006 US production of styrene was 11.4 million pounds (1), produced principally by catalytic dehydrogenation of ethylbenzene. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. Planning a summer barbecue this weekend or stocking up for Labor Day? The new announcement from the World Health Organisation will be published by IARC as a Monograph, authored by 23 handpicked researchers from around the world, including Professor Henrik Kolstad. (styrene and [cancer or neoplasms] and [epidemiology or mortality or in-cidence]), without restriction of lan-guage or date of publication, as well as the references in the recent IARC Monograph1 and NTP Background Document.8 In a second PubMed search, we used the terms ([lymphoma or Hodgkin or Hodgkin’s or leukemia or … Styrene is … 100-42-5. Hence, based on both animal and human cancer studies and genotoxic findings including clastogenicity and DNA damage in workers as well as on other supportive and biologically plausible mechanistic results, styrene and styrene-7,8-oxide should be considered as presenting carcinogenic risks to humans, particularly for lymphatic/hematopoietic cancers. Significant improvements have been made to the working environments in the Danish reinforced plastics industry in recent years, but globally the problem has not been solved. Lung Resection For Non-Small-Cell Lung Cancer - A New Risk Score To Predict Major Perioperative Complications. Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. Conflict of interest statement: None declared. 16 . Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. Enough already The styrene toxicity database available today provides ample support for a conclusion of “no concern” for styrene and cancer. We offer the following regional Styrene coverage to keep you informed of factors and developments affecting prices in the Europe Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene In its pure form, styrene has a sweet smell. Manufactured styrene may contain aldehydes, which give it a sharp, unpleasant odor. Experience shows that countries respond differently to the warnings of the monographs. wind turbines or yachts. P.F.I. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". Styrene Officially Linked to Cancer Styrene Officially Linked to Cancer. For possible other human cancer sites related to styrene exposures, NTP asserts ‘Studies in the reinforced-plastics industry provided evidence that suggests a possible association between styrene exposure and cancer of the esophagus or pancreas.’ (1). This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat‐building facilities, extending follow‐up 5 years. hide. "After 40 years in limbo: Styrene is probably carcinogenic." Have any problems using the site? (6) review on behalf of Styrene Information and Research Center, a styrene industry organisation, was presented by co-author P. Cole to the National Toxicology Program’s (NTP) Board of Scientific Counsellors open-to-the-public Peer Review of styrene (7). Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Copyright © 2020 Oxford University Press and United Kingdom Environmental Mutagen Society. One of the reasons why the results carry a lot of weight with the WHO is that Kolstad and his colleagues have been able to compare the research data from the cancer patients with measurements of styrene exposure in the Danish reinforced plastics industry over time. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … This has led to Germany forbidding the driving of older diesel cars in a number of cities. was a member of the NTP RoC Styrene Expert Panel Meeting, July 2008. "After 40 years in limbo: Styrene is probably carcinogenic." The study has involved a comprehensive linkage of registers, where the researchers used the central business register , along with various other company registers, to identify the relevant companies and their employees. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. Both are genotoxic and form DNA adducts in humans. CAS No. Ultimately, more emphasis needs to be directed towards primary prevention as the most reliable channel for reducing or eliminating cancer burdens, especially among workers exposed to known carcinogens and mutagens (16,26,27). IARC in 2002, nearly 10 years ago, concluded that the evidence was already considerable but not fully sufficient for causality (5). For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. Moreover, in the interests of public and occupational health, we suggest that authors be more cautious in their casual acceptance of industry papers and reviews of epidemiological study results related to occupational exposure to styrene (or other chemicals). and their health effects. Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. Elevated incidence or mortality of lymphohematopoietic cancers was observed in large occupational cohorts of workers in the reinforced … 2 comments . After 40 years in limbo: Styrene is probably carcinogenic. Do RNA vaccines obviate the need for genotoxicity studies? To understand … Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. "Possibly carcinogenic and should be investigated more closely." EcoWatch, July 29, 2014 July 30, 2014. The World Health Organization’s International Agency for Research on Cancer (IARC) has now upgraded the cancer-causing status of the common plastic ingredient styrene. Is that only an issue if the tv gets smashed or something? Reasonably Anticipated to Be a Human Carcinogen. The reports are prepared by the International Agency for Research on Cancer (IARC), which is one of the WHO's expert bodies. share. Styrene is a colorless liquid that evaporates easily. review (6,7). California Health & Safety Code Section 25249.6. Four styrene laden products to ditch. Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. ScienceDaily, 30 May 2018. Title: Styrene Cancer Warning Upheld. It is not intended to provide medical or other professional advice. Moreover, in 2009 (1), the US Department of Health and Human Service’s NTP declared ‘Styrene is reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity in humans, sufficient evidence of carcinogenicity in experimental animals, and supporting mechanistic data.’, NTP further affirms, regarding human studies (1), that: ‘The limited evidence for the carcinogenicity of styrene in humans is based on studies of workers exposed to styrene that showed (1) increased mortality from or incidence of cancer of the lymphohematopoietic system and (2) increased levels of DNA adducts and genetic damage in lymphocytes from exposed workers. One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. (2), however, dismissed IARC’s Working Group evaluation in 2002 (5) by iterating from the 2009 Boffetta et al. However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. Henrik Kolstad emphasizes that the Danish register findings reflect the sins of the past. However, it was not possible to establish whether the American workers contracted leukaemia from handling styrene or from butadiene, a chemical, which is styrene's permanent companion in the production of synthetic rubber -- and this is where the Danish register-based studies come into the picture. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’. www.sciencedaily.com/releases/2018/05/180530113105.htm (accessed December 31, 2020). The reason for different classifications from different organizations is partly a … It is important … The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. In 2011, styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a ‘poison scandal’ in the Danish media; but now a registry study of more than 72,000 employees from more than 400 companies that have been exposed to styrene during production of glassfibre reinforced plastics, has not found an increased incidence of a wide range of cancer … To further explore the relationship between work-related styrene exposure and cancer, NIOSH investigators compared styrene exposures to cancer deaths among 5,201 former workers in two boat-building facilities in Washington State. The critical impact of tumor size in predicting cancer special survival for T3aM0M0 renal cell carcinoma: A proposal of an alternative T3aN0M0 stage. 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